In cases of misfires these are main steps to follow:
Move spark plug from another cylinder not having the misfire. If the misfire follows the cylinder, change the spark plugs. If the spark plug is good, then change the coli pack from another known good cylinder. If misfire follows, change the coil pack. If this doesn't work, move a known good injector from another cylinder. If misfire follows the injector then replace.
There are also a set of o-rings around the fuel injector and collar. If the above does not work, take some carburetor cleaner and spray around the injector while running. You will here a sucking noise and engine RMP increase if it's bad. Replace the o-rings if this is the case.
It's a matter of deduction with a cylinder misfire. You also don't have to spend a lot of money replacing plugs, coil packs and injectors. Move the pieces from the known good cylinders to see if the problem follows.
This recently happened on my 2008 LT on cylinder 4. I went thru the steps above and still had the problem on cylinder 4. Once I sprayed the carb cleaner around injector 4, I heard the sucking of the fluid and RPM kick up briefly. Replaced the o-rings and all is well.